The mission of the Clinical Translational Glycoscience Research Center (CTGRC) at Georgetown University is to facilitate translational glycoscience studies in biomedical research. Our goal is to understand the function of glycoproteins and to enable their quantitative analysis in the context of the pathophysiology of human diseases. To this end, we develop analytical methods for mass spectrometric characterization of glycoproteins, informatics tools for the glycoproteomics data interpretation, and model systems for the studies of glycoproteins at the level of the molecule, cell, and organism. We want to understand how glycosylation pathways integrate with other biomolecules to adjust the flow of information in biological systems. We therefore develop methods for reliable quantitative analysis of the glycoconjugates and apply these techniques to collaborative studies aimed to advance biomedical research.
The CTGRC at Georgetown University started as a fusion of efforts at the Goldman and Edwards laboratories, that is fusion of analytical glycoscience and protein biochemistry (Goldman lab) and informatics of proteins and their glycosylation (Edwards lab). The joint research effort led to the development of glycoproteomics methods that are now applied to translational biomedical studies in collaboration with a growing number of research groups.
Our paper on the regulation of SULF2 activity by galectin3 binding protein is now under review
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec…
Congrats to Reem Aljuhani on a travel award to present a poster at the ASBMB meeting in San Antonio
Purification and in vitro Characterization of Human Extracellular Heparan 6-O-Endo-Sulfatases Sulf1 and Sulf2. Aljuhani R, Benicky J, Zhang L, Liu J, Pomin VH, Goldman R. ASBMB San Antonio, March…
Drs. Benicky and Panigrahi present at the 2023 Annual SfG meeting in Hawaii
A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers. Benicky J, Liu J, Wang Z, Pagadala V, Panigrahi A, Sanda M, Su G, and Goldman R. Society for Glycobiology Annual…
Congrats to Dr. Mukherjee on a study showing SULF2-mediated invasion of HNSCC cells co-cultured with primary CAF
Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A,…