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Glycan-dependent interactions of SARS CoV2

April 8th, 2022

Host Cell Glycocalyx Remodeling Reveals SARS-CoV-2 Spike Protein Glycomic Binding Sites. Ying Sheng, Anita Vinjamuri, Michael Russelle S. Alvarez, Yixuan Xie, Marisa McGrath, Siyu Chen, Mariana…

Dr. Goldman presents at US HUPO 2022

April 8th, 2022

“Heparan Sulfate 6-O-endosulfatases in HNSCC and Other Malignancies” talk by Rado Goldman at the US HUPO 2022 18th Annual Conference in Charleston, SC February 28 in Parallel Session 4:…

Collagen organization regulates tumor progression

April 8th, 2022

A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy. Di Martino JS, Nobre AR, Mondal C, Taha I, Farias EF, Fertig EJ, Naba A, Aguirre-Ghiso JA, Bravo-Cordero JJ. Nat…

Collagen regulates tumors by immunosuppression

April 8th, 2022

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y,…

Glycans in SARS-CoV-2 antibody production

May 7th, 2021

 Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production. Xiaohui Zhao, Huan Chen, Hongliang Wang. Front Mol Biosci 2021 Apr 13;8:629873. eCollection 2021. doi:…

Therapeutic implications of the inhibition of SULF2

May 7th, 2021

SULF2 monoclonal antibody 5D5 suppresses human cholangiocarcinoma xenograft growth via regulation of a SULF2-PDGFRβ-YAP signaling axis. Luo X, Campbell NA, He L, O’Brien DR, Singer MS,…

A nice study of SARS-CoV-2 binding to heparan sulfate

May 7th, 2021

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate. Vaibhav Tiwari, Ritesh Tandon, Nehru Viji Sankaranarayanan, Jacob C. Beer, Ellen K.…

Advances in the studies of SARS-CoV-2 O-glycosylation

May 7th, 2021

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure. Zhijue Xu, Xin Ku, Jiaqi Tian, Han Zhang, Jingli Hou, Can Zhang, Jingjing…

Heparan Sulfate assists with SARS-CoV-2 cell entry

October 21st, 2020

Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN,…