Heparan Sulfation in HNSC and Other Malignancies
Heparan 6-O-endosulfatases, SULF1 and SULF2, are significantly elevated in head and neck squamous cell carcinoma (HNSC) tissues at all stages of the disease progression and are associated with poor…
Projects
Quantitative Glycoproteomics and Glycoprotein Informatics
Glycosylation is a set of highly diverse pathways that modify protein chemistry, their interactions and many related biological processes including cell-cell or host-pathogen interactions driving…
Glycobiology of Immune Responses – Checkpoints, Immunoglobulins, Covid19
Glycoscience is a cornerstone of modern immunology. Glycan/glycoprotein structures and their interactions with carbohydrate recognition proteins called lectins define frequently what represents…
Glycoprotein Synthesis and Biochemistry of the Secretory Pathway
Analysis of the glycoproteins in cell and animal models allows exploration of the rules of glycoprotein synthesis in the ER/Golgi secretory compartments and production of the glycoproteins for…
Glycoproteins in Cancer Diseases
Cancer diseases are not typically associated with mutations in the glycosylation pathways but glycosylation is frequently altered in their progression. We study most actively the progression of…