The mission of the Clinical Translational Glycoscience Research Center (CTGRC) at Georgetown University is to facilitate translational glycoscience studies in biomedical research. Our goal is to understand the function of glycoproteins and to enable their quantitative analysis in the context of the pathophysiology of human diseases. To this end, we develop analytical methods for mass spectrometric characterization of glycoproteins, informatics tools for the glycoproteomics data interpretation, and model systems for the studies of glycoproteins at the level of the molecule, cell, and organism. We want to understand how glycosylation pathways integrate with other biomolecules to adjust the flow of information in biological systems. We therefore develop methods for reliable quantitative analysis of the glycoconjugates and apply these techniques to collaborative studies aimed to advance biomedical research.
The CTGRC at Georgetown University started as a fusion of efforts at the Goldman and Edwards laboratories, that is fusion of analytical glycoscience and protein biochemistry (Goldman lab) and informatics of proteins and their glycosylation (Edwards lab). The joint research effort led to the development of glycoproteomics methods that are now applied to translational biomedical studies in collaboration with a growing number of research groups.
Our collaboration with colleagues at the University of Mississippi reveals how glycan polymers inhibit Sulf-2 activity
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec…
Congrats to Dr. Panigrahi & colleagues on a spatially resolved proteomics study of FFPE tissues of HNSCC patients
dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples. Panigrahi A, Hunt AL, Assis D, Willetts M, Kallakury BV, Davidson B, Ahn J, Conrads TP, Goldman R. ACS Omega. 2025…
Our collaborative paper with Glycan Therapeutics on MS analysis of SULF activity is a Glycobiology Editor’s Choice
Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research. Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman…
Congrats to Dr. Mukherjee on a study showing SULF2-mediated invasion of HNSCC cells co-cultured with primary CAF
Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A,…