Archive: News
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SULFs in cancer metastasis
6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets. Han M, Zhu H, Chen X, Luo X. Am J Cancer Res. 2024 Feb 25;14(2):897-916. doi: 10.
Category: News
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Glycoproteins and cancer-stromal cell interactions mediate resistance to HER2-targeting therapies
Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies. Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z,
Category: News
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Mucin-selective proteolytic degradation
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malak
Category: News
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A review of glycosaminoglycan biology
A biological guide to glycosaminoglycans: current perspectives and pending questions. Ricard-Blum S, Vivès RR, Schaefer L, Götte M, Merline R, Passi A, Heldin P, Magalhães A, Reis CA, Skandalis SS, K
Category: News
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Congrats to Dr. Pritha Mukherjee on a paper on inhibitors of HNSCC cell invasion
Aspartate β-Hydroxylase Is Upregulated in Head and Neck Squamous Cell Carcinoma and Regulates Invasiveness in Cancer Cell Models. Mukherjee P, Zhou X, Galli S, Davidson B, Zhang L, Ahn J, Aljuhani R,
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Congrats to Amy Lum
Congrats to Amy Lum, undergraduate student researcher, on receipt of a Laidlaw scholarship supporting her research at the CTGRC.
Category: News
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A novel way to model protein-carbohydrate interactions
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Xinheng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang,
Category: News
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Congrats to Dr. Aswini Panigrahi on a paper showing SULF2 inhibition by galectin-3-binding protein
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. Mol Cell Proteomics. 2024 May 31
Category: News
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Our proteomics study of OSCC survival will be presented at the 2024 ASMS meeting in Anaheim
A study of LCM microdissected tumors analyzing proteins in tumor epithelial and stroma fractions associated with node positivity and poor survival of HNSCC patients. DIA-PASEF proteomic analysis of H
Category: News
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Our paper on the regulation of SULF2 activity by galectin3 binding protein is now under review
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec 21:2023.12.20.5
Category: News