Archive: News
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SULF2/TIMP3 axis connects hepatic fibrosis to HCC
Zhang S, Sun P, Zhang J, Li X. Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis. Neuro Endocrin
Category: News
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SULF1 drives TME remodeling in PDAC
Xu J, Qian K, Ding Y, Cheng J, Zhang X, Huang Y, Liu B. Multi-Omic and Spatial Profiling Identifies an Epithelial DKK1 Associated with Microenvironmental Remodeling in Pancreatic Ductal Adenocarcinom
Category: News
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Function of the SULF hydrophilic domain
Demongin C, Tao J, El Omrani N, Uchimura K, Basdevant N, Daniel R. The hydrophilic domain of HSulf Endosulfatases: an intrinsically disordered region governing enzyme functions and therapeutic potent
Category: News
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Haleigh Brown joins our study of SULF inhibitors for her MS project
Category: News
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Congrats to Pritha on her paper on SULF1+CAF in HNSCC
Mukherjee P, Benicky J, Panigrahi A, Ailles L, Goldman R. SULF1 in Cancer Associated Fibroblasts Promotes Invasion in Head and Neck Cancer Cell Lines. Cancer Med. 2026 Jan;15(1):e71540. doi: 10.1002/
Category: News
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Updated findings on the inhibition of SULF enzymes by a fucosylated GAG isolated from a sea cucumber.
Farrag M, Aljuhani R, Benicky J, Al Ahmed H, Misra SK, Mishra SK, Sharp JS, Doerksen RJ, Goldman R, Pomin VH. Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibit
Category: News
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Reem Aljuhani published our results on the production and inhibition of SULF1
Aljuhani R, Benicky J, Panigrahi A, Mukherjee P, Sanda M, Zhu S, Nováková Z, Pomin VH, Liu J, Davidson B, Bařinka C, Goldman R. Production and inhibition of human Heparan 6-O-Endosulfatase SULF1. Gly
Category: News
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SULF1 in endothelial senescence and atherosclerosis
Jiang MT, Wan SL, Shen XY, Zhang ZB, He ZQ, Hu YX, Liang C. SULF1's Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics. J Inflamm Res. 2025 Dec 16;
Category: News
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SULF1 in reward and aversion learning
Miya K, Ohta K, Keino-Masu K, Okada T, Mizuno S, Takahashi S, Macpherson T, Hikida T, Masu M. Essential Roles of Heparan Sulfate Endosulfatase Sulf1 in Reward and Aversion Learning Through Distinct D
Category: News
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SULF2 inhibition sensitizes TNBC to paclitaxel
Manouchehri JM, Datta J, Marcho LM, Stover D, Ganju RK, Ramaswamy B, Carson WE, Mittra A, Zhang X, Schnell PM, Yue Y, Rubinstein MP, Cherian MA. Sulfatase 2 inhibition sensitizes triple-negative brea
Category: News