Archive: News

• Reem Aljuhani presents a poster on SULF1 structure-activity at the NIH-FDA Glycoscience Research Day

  Aljuhani, R., Benicky, J., Panigrahi, A., Mukherjee, P., Nováková, Z., Bařinka, C., Liu, J., Goldman, R. Purification and in vitro Characterization of Human Extracellular Heparan 6-O-endosulfatases S

  Category: News

• Dr. Panigrahi shows that Galectin-3-Binding Proptein is a specific and selective inhibitor of Sulf-2

  Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. Mol Cell Proteomics. 2024 Jul;23

  Category: News

• Amy Lum is selected to present at the Laidlaw Conference at Columbia University

  Amy Lum, Julius Benicky, Radoslav Goldman. Generation of Galectin-3-Binding Protein (LG3BP) F357W Mutant as a Crucial Resource for Characterization of Sulf-2/LG3BP Interaction.

  Category: News

• SULF1+ CAF support progression of colorectal cancer

  Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer. Wang H, Chen J, Chen X, Liu Y, Wang J, Meng Q, Wang H, He Y

  Category: News

• SULFs regulate bone marrow hematopoiesis

  Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis. Whitehead AK, Wang Z, Boustany RJ, Vivès RR, Lazartigues E, Liu J, Siggins RW, Yue X. Matrix Biol. 2024 Dec

  Category: News

• A nice paper showing how PDX engraftment predict survival of OSCC patients

  Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes. Waas M, Karamboulas C, Wu BZ, Khan S, Poon S, Meens J, Govindarajan M, Khoo A, Mejia-Guerrero S,

  Category: News

• Our collaboration with Glycan Therapeutics on MS quantification of SULF activity is selected a Glycobiology Editor’s Choice publication

  Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research. Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman R,

  Category: News

• Dr. Panigrahi et al. describe an LCM-LC-MS/MS method for spatially resolved proteomics of archived FFPE tissues of OSCC patients

  dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples. Panigrahi A, Hunt AL, Assis D, Willetts M, Kallakury BV, Davidson B, Ahn J, Conrads TP, Goldman R. ACS Omega. 2025 M

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• Our collaboration with Dr. Pomin et al. shows how glycan polymers inhibit Sulf-2 activity

  Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan. Farrag M, Aljuhani R, Benicky J, Al Ahmed H, Misr

  Category: News

• Congrats to Dr. Mukherjee on a study showing SULF2-mediated invasion of HNSCC cells co-cultured with primary CAF

  Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A, Aljuha

  Category: News