Archive: News
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Congrats to Panigrahi on two papers advancing microflow LC-MS/MS-PRM and the detection of liver fibrosis
A multiplexed microflow LC-MS/MS-PRM assay for serologic quantification of IgG N- and HPX O- glycoforms in liver fibrosis. Panigrahi A, Zhang L, Benicky J, Sanda M, Ahn J, Goldman R. Sci Rep. 2023 Ja
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SULF1 downregulation by EZH2 in chondrosarcoma leads to poor outcomes
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC, C
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Dr. Edwards publishes on glycan vocabulary standardization
The glycan structure dictionary-a dictionary describing commonly used glycan structure terms. Vora J, Navelkar R, Vijay-Shanker K, Edwards N, Martinez K, Ding X, Wang T, Su P, Ross K, Lisacek F, Haye
Category: News
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A nice paper on an exosome-based detection of HCC
HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J, Z
Category: News
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Congrats to Dr. Sanda on the first use of a SIS glycopeptide MS assay for the quantification of IgG glycoforms
LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, Khan K, Kroemer A, Wang LX, Goldman R. J P
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SULF2 mediates activation of synovial fibroblasts in rheumatoid arthritis
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts. Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J
Category: News
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Continued search for effective inhibitors of the SULFs
Design and Synthesis of 1-O- and 6'-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors. Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Hung SC. Front Chem. 2022 Jul 13;10:947
Category: News
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Our updated results on the SULFs
An update on the function of the heparan 6-O-endosulfatases (SULF1 and SULF2) in cancer disease is now under review and deposited on bioRxiv.
Category: News
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Reem Aljuhani successfully defends her Phase 2 PhD exam
Congrats to Reem Aljuhani on a successful Phase 2 exam in her PhD program!! She presented a paper on “Heparan sulfate binding proteins dependent on 6-O-sulfation in Head and neck squamous cells carci
Category: News
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Dr. Goldman expands collaborations with scientist at the Czech National Academy of Sciences during his sabbatical
The studies target analysis of the structure and function of the heparan 6-O-endosulfatases and are designed to generate inhibitors and antibodies specific to these important enzymes.
Category: News