Aspirin reduces SARS-CoV-2 binding to ACE2 via altered glycosylation of the spike protein

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Perico L, Bovio A, Tomasoni S, Trionfini P, Cerullo D, Corna D, Pezzotta A, Locatelli M, Alberti M, Benigni A, Remuzzi G. Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2. Front. Immunol., 06 January 2026, Volume 16 – 2025, doi: 10.3389/fimmu.2025.1706997