Our collaboration with colleagues at the University of Mississippi reveals how glycan polymers inhibit Sulf-2 activity

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Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec 21:2023.12.20.572603. doi: 10.1101/2023.12.20.572603. Preprint. PMID: 38187586

Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan. Farrag M, Aljuhani R, Benicky J, Al Ahmed H, Misra SK, Mishra SK, Sharp JS, Doerksen RJ, Goldman R, Pomin VH. Glycobiology. 2025 Apr 23;35(6):cwaf025. doi: 10.1093/glycob/cwaf025. PMID: 40302034