Our collaboration with Dr. Pomin et al. shows how glycan polymers inhibit Sulf-2 activity

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Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan. Farrag M, Aljuhani R, Benicky J, Al Ahmed H, Misra SK, Mishra SK, Sharp JS, Doerksen RJ, Goldman R, Pomin VH. Glycobiology. 2025 Apr 23;35(6):cwaf025. doi: 10.1093/glycob/cwaf025. PMID: 40302034