SULF2 mediates activation of synovial fibroblasts in rheumatoid arthritis

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Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts. Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S. Cell Mol Immunol. 2022 Oct;19(10):1185-1195. doi: 10.1038/s41423-022-00913-x. PMID: 36068294.