Archive: News
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CTGRC Virtual Posters at the 2021 NIH & FDA Glycoscience Research Day on June 1st
Conference website and registration. “Disialo T antigen in the progression of liver disease”, Miloslav Sanda, Julius Benicky, and Radoslav Goldman. “Purification and characterization of human r
Category: News
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Therapeutic implications of the inhibition of SULF2
SULF2 monoclonal antibody 5D5 suppresses human cholangiocarcinoma xenograft growth via regulation of a SULF2-PDGFRβ-YAP signaling axis. Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alao
Category: News
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Mucin domain-targeting proteases open new avenues in mucin research
Classification, structural biology, and applications of mucin domain-targeting proteases. Shon DJ, Kuo A, Ferracane MJ, Malaker SA. Biochem J. 2021 Apr 30;478(8):1585-1603. doi: 10.1042/BCJ20200607
Category: News
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A nice study of SARS-CoV-2 binding to heparan sulfate
Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate. Vaibhav Tiwari, Ritesh Tandon, Nehru Viji Sankaranarayanan, Jacob C. Beer, Ellen K. K
Category: News
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Advances in the studies of SARS-CoV-2 O-glycosylation
Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure. Zhijue Xu, Xin Ku, Jiaqi Tian, Han Zhang, Jingli Hou, Can Zhang, Jingjing S
Category: News
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A nice summary of Glycosaminoglycan–Protein Interactions
Glycosaminoglycan-Protein Interactions: The First Draft of the Glycosaminoglycan Interactome. Vallet SD, Clerc O, Ricard-Blum S. J Histochem Cytochem. 2021 Feb;69(2):93-104. doi: 10.1369/002215542094
Category: News
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A nice development in SULF-2 research: it is a proteoglycan
“Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity” Rana El Masri, Amal Seffouh, Caroline Roelants, Ilham Seffouh, Evelyne Gout, Juli
Category: News
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A paper on the glycopeptides of SARS CoV-2 displayed by MHCII to be published soon in Cell Reports
Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells. Parker R, Partridge T, Wormald C, Kawahara R, Stalls V, Aggelakopoulou M, Parker J, Doherty R
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Sialic acid on ACE2 and heparan sulfation modify SARS-CoV-2 infectivity
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yua
Category: News
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Dr. Sanda collaborates with SCIEX researchers on CESI TripleTOF LC-MS/MS analysis of Adalimumab glycoforms
The results were published in a Sciex release (https://sciex.com/content/dam/SCIEX/pdf/tech-notes/all/CESI_mAb.pdf) and presented by Mila at the US HUPO 2021 conference, virtual, 03/08/2021: “Site-sp
Category: News