Archive: News
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Congrats to Reem Aljuhani on a travel award to present a poster at the ASBMB meeting in San Antonio
Purification and in vitro Characterization of Human Extracellular Heparan 6-O-Endo-Sulfatases Sulf1 and Sulf2. Aljuhani R, Benicky J, Zhang L, Liu J, Pomin VH, Goldman R. ASBMB San Antonio, March 202
Category: News
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Drs. Benicky and Panigrahi present at the 2023 Annual SfG meeting in Hawaii
A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers. Benicky J, Liu J, Wang Z, Pagadala V, Panigrahi A, Sanda M, Su G, and Goldman R. Society for Glycobiology Annual Meeti
Category: News
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Congrats to Dr. Mukherjee on a study showing SULF2-mediated invasion of HNSCC cells co-cultured with primary CAF
Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A, Aljuha
Category: News
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Dr. Panigrahi et al. share a preprint on the regulation of SULF2 activity by Galectin3 binding protein in BioRxiv
Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec 21:2023.12.20.5
Category: News
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SULF2 is a target gene regulated by TGFb via LINC00313 in cholangiocarcinoma
TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma. Papoutsoglou P, Pineau R, Leroux R, Louis C, L'Haridon A, Foretek D, Morillon A, Banales JM, Gilot
Category: News
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SULF1 positive fibroblast regulate lizard tail regeneration induced by hedgehog signaling
Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis. Vonk AC, Zhao X, Pan Z, Hudnall ML, Oakes CG, Lopez GA, Hasel-Kolossa
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Structure-function of an exostosin heterodimer (EXT1 and EXT2) that extends HSPG polymers
Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Li H, Chapla D, Amos RA, Ramiah A, Moremen KW, Li H. Nat Chem Biol. 2023 May;19(5):565-574. doi: 10.1038/s41589-022-01
Category: News
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EXTL3 selects heparan sulfate synthesis over chondroitin sulfation of glycosaminoglycans
Molecular mechanism of decision-making in glycosaminoglycan biosynthesis. Sammon D, Krueger A, Busse-Wicher M, Morgan RM, Haslam SM, Schumann B, Briggs DC, Hohenester E. Nat Commun. 2023 Oct 13;14(1)
Category: News
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Our paper on SULF2-promoted invasiveness of HNSCC just published
Our paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou, Julius Be
Category: News
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Josh Tu joins the CTGRC for his PhD research rotation
Josh is a first year PhD student of Biochemistry and Molecular & Cellular Biology. He studies inhibition of the heparan 6-O-endosulfatase enzymes by marine fucosylated chondroitins as part of his res
Category: News