Archive: News
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Our review of heparan sulfatase mechanism of action and inhibition
Mayieka M, Benicky J, Goldman R, Huang X. Sulfatases: Catalytic Mechanism, Substrate Preferences, and Carbohydrate-Based Inhibitor Design. Israel Journal of Chemistry. 2025 Dec 20. doi: 10.1002/ijch.
Category: News
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Gregory Furletti will present our study of SULF1 in HNSCC at the USCAP in San Antonio
Furletti G, Llaguno Guerrero TJ, Schrom EC, Goldman R, Davidson B, Kallakury B. Spatial Patterning Analysis of SULF1 Expression at Tumor–Stroma Interfaces in Head and Neck Squamous Cell Carcinoma: A
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Congrats to Pritha on a SULF1 paper accepted in Cancer Medicine
Mukherjee P, Benicky J, Panigrahi A, Ailles L, Goldman R. SULF1 in cancer associated fibroblasts promotes invasion in head and neck cancer cell lines. Cancer Medicine, in press
Category: News
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Reem Aljuhani presents a poster on SULF1 structure-activity at the NIH-FDA Glycoscience Research Day
Aljuhani, R., Benicky, J., Panigrahi, A., Mukherjee, P., Nováková, Z., Bařinka, C., Liu, J., Goldman, R. Purification and in vitro Characterization of Human Extracellular Heparan 6-O-endosulfatases S
Category: News
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Dr. Panigrahi shows that Galectin-3-Binding Proptein is a specific and selective inhibitor of Sulf-2
Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. Mol Cell Proteomics. 2024 Jul;23
Category: News
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Amy Lum is selected to present at the Laidlaw Conference at Columbia University
Amy Lum, Julius Benicky, Radoslav Goldman. Generation of Galectin-3-Binding Protein (LG3BP) F357W Mutant as a Crucial Resource for Characterization of Sulf-2/LG3BP Interaction.
Category: News
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SULF1+ CAF support progression of colorectal cancer
Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer. Wang H, Chen J, Chen X, Liu Y, Wang J, Meng Q, Wang H, He Y
Category: News
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SULFs regulate bone marrow hematopoiesis
Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis. Whitehead AK, Wang Z, Boustany RJ, Vivès RR, Lazartigues E, Liu J, Siggins RW, Yue X. Matrix Biol. 2024 Dec
Category: News
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A nice paper showing how PDX engraftment predict survival of OSCC patients
Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes. Waas M, Karamboulas C, Wu BZ, Khan S, Poon S, Meens J, Govindarajan M, Khoo A, Mejia-Guerrero S,
Category: News
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Our collaboration with Glycan Therapeutics on MS quantification of SULF activity is selected a Glycobiology Editor’s Choice publication
Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research. Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman R,
Category: News