Archive: News

• Amy Lum is selected to present at the Laidlaw Conference at Columbia University

  Amy Lum, Julius Benicky, Radoslav Goldman. Generation of Galectin-3-Binding Protein (LG3BP) F357W Mutant as a Crucial Resource for Characterization of Sulf-2/LG3BP Interaction.

  Category: News

• SULF1+ CAF support progression of colorectal cancer

  Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer. Wang H, Chen J, Chen X, Liu Y, Wang J, Meng Q, Wang H, He Y

  Category: News

• SULFs regulate bone marrow hematopoiesis

  Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis. Whitehead AK, Wang Z, Boustany RJ, Vivès RR, Lazartigues E, Liu J, Siggins RW, Yue X. Matrix Biol. 2024 Dec

  Category: News

• A nice paper showing how PDX engraftment predict survival of OSCC patients

  Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes. Waas M, Karamboulas C, Wu BZ, Khan S, Poon S, Meens J, Govindarajan M, Khoo A, Mejia-Guerrero S,

  Category: News

• Our collaboration with Glycan Therapeutics on MS quantification of SULF activity is selected a Glycobiology Editor’s Choice publication

  Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research. Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman R,

  Category: News

• Dr. Panigrahi et al. describe an LCM-LC-MS/MS method for spatially resolved proteomics of archived FFPE tissues of OSCC patients

  dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples. Panigrahi A, Hunt AL, Assis D, Willetts M, Kallakury BV, Davidson B, Ahn J, Conrads TP, Goldman R. ACS Omega. 2025 M

  Category: News

• Our collaboration with Dr. Pomin et al. shows how glycan polymers inhibit Sulf-2 activity

  Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan. Farrag M, Aljuhani R, Benicky J, Al Ahmed H, Misr

  Category: News

• Congrats to Dr. Mukherjee on a study showing SULF2-mediated invasion of HNSCC cells co-cultured with primary CAF

  Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A, Aljuha

  Category: News

• Our collaborative paper with Glycan Therapeutics on MS analysis of SULF activity is a Glycobiology Editor’s Choice

  Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research. Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman R,

  Category: News

• Our collaboration with colleagues at the University of Mississippi reveals how glycan polymers inhibit Sulf-2 activity

  Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec 21:2023.12.20.5

  Category: News