Archive: News
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Reem Aljuhani presents her studies of heparan-6-O-endosulfatatses at a BMCB seminar series
Reem presents her discoveries on the “Expression and characterization of extracellular heparan 6-O-endosulfatases Sulf1 and Sulf2” at the Biochemistry and Molecular & Cellular Biology (BMCB) seminar
Category: News
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New details on the function of N-glycans in the FcγRIIIa interaction with IgG
A paper by Van Coillie et al. shows that afucosylated N-glycans of IgG have highest affinity for the oligomannose FcγRIIIa, a glycan structure commonly found on Asn162 on FcγRIIIa expressed by NK cel
Category: News
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Dr. Panigrahi presents a poster on the detection of liver fibrosis at the 2023 SFG meeting in Hawaii
His poster “Serologic LC-MS/MS-PRM of IgG N-glycoform G0FN and sialylated HPX O-glycoforms effectively identifies progressing liver fibrosis” is co-authored byAswini Panigrahi1,2, Lihua Zhang1,2, Jul
Category: News
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Dr. Benicky presents a poster on SULF activity measurements at the 2023 SFG meeting in Hawaii
His poster “A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers” is co-authored by Julius Benicky1, Jian Liu2, Zhangjie Wang3, Vijayakanth Pagadala3, Aswini Panigrahi1, Mi
Category: News
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Discovery of global inhibitors of cellular glycosylation
A paper by Sorensen et al. identifies two compounds that mediate reversible fragmentation of the Golgi system without affecting secretion; this leads to expression of truncated O-glycans or to the in
Category: News
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SULF2 derives mainly from cancer associated fibroblasts in hepatocellular cancers
A paper by Zaki et al. shows that SULF2 is produced in part by cancer cells but that majority of the SULF2 enzyme is supplied by cancer assicated fibroblasts which correlates with poor prognosis. doi
Category: News
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Dr. Mukherjee et al. share a preprint on the SULF2-supported invasion of HNSC cells in BioRxiv
The paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou, Julius Be
Category: News
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An update on the glycoproteomics of the TIM family of immune checkpoint inhibitors
A paper by Chongsaritsinsuk et al. expose mucin-type O-glycosylation of the T cell immunoglobulin and mucin-domain containing family of proteins (TIMs) and their structure-function models. doi:10.103
Category: News
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Congrats to Dr. Benicky on a paper on the quantification of SULF activity
A 6-O-endosulfatase activity assay based on synthetic heparan sulfate oligomers. Benicky J, Sanda M, Panigrahi A, Liu J, Wang Z, Pagadala V, Su G, Goldman R. Glycobiology. 2023 33(5):384-395. doi: 1
Category: News
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SULF2 is supplied to HCC tissues by cancer associated fibroblasts
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma? Zaki MYW, Alhasan SF, Shukla R, McCain M, Laszczewska M, Geh D, Patman GL, Televantou D, Whitehea
Category: News