Archive: News

• SULF2, GPC3, and SDC1 in serum predict poor outcomes in HCC

  Sulfatase 2 Along with Syndecan 1 and Glypican 3 Serum Levels are Associated with a Prognostic Value in Patients with Alcoholic Cirrhosis-Related Advanced Hepatocellular Carcinoma. Mouhoubi N, Bamba-

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• Regulation of heparan sulfate assembly by TFCP2

  TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. Basu A, Champagne RN, Patel NG, Nicholson ED, Weiss RJ. J Biol Chem. 2023 Jun;299(6):104713. doi: 10.1016/j.

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• An update on fragmentation of glycopeptides from Dr. Sanda’s group

  HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J, Z

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• Congrats to Drs. Sanda and Panigrahi on significantly improved LC-MS/MS quantification of glycopeptides

  LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, Khan K, Kroemer A, Wang LX, Goldman R. J P

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• Dr. Goldman presents on Heparan 6-O-endosulfatases in cancer diseases

  Dr. Goldman presents on the Heparan 6-O-endosulfatases in cancer diseases at the Czech Annual Cancer Research Meeting in Olomouc, December 1 2022: http://cancermeeting.cz/wp-content/uploads/2022/12/c

  Category: News

• SULF1 is associated with Gleason Score and predicts prostate cancer outcomes

  The Development of a Gleason Score-Related Gene Signature for Predicting the Prognosis of Prostate Cancer. Yimamu Y, Yang X, Chen J, Luo C, Xiao W, Guan H, Wang D. J Clin Med. 2022 Dec 1;11(23):7164.

  Category: News

• Congrats to Dr Yang and co-authors on paper summarizing the impact of the heparan 6-O-endosulfatases in HNSC and other cancers

  Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies. Yang Y, Ahn J, Edwards NJ, Benicky J, Rozeboom AM, Davidson B, Karamboulas C,

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• An interesting paper on urinary and plasma GAGs in cancer detection

  Noninvasive detection of any-stage cancer using free glycosaminoglycans. Bratulic S, Limeta A, Dabestani S, Birgisson H, Enblad G, Stålberg K, Hesselager G, Häggman M, Höglund M, Simonson OE, Stålber

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• Congrats to Panigrahi on two papers advancing microflow LC-MS/MS-PRM and the detection of liver fibrosis

  A multiplexed microflow LC-MS/MS-PRM assay for serologic quantification of IgG N- and HPX O- glycoforms in liver fibrosis. Panigrahi A, Zhang L, Benicky J, Sanda M, Ahn J, Goldman R. Sci Rep. 2023 Ja

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• SULF1 downregulation by EZH2 in chondrosarcoma leads to poor outcomes

  EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC, C

  Category: News