Archive: News
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SULF2 is a target gene regulated by TGFb via LINC00313 in cholangiocarcinoma
TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma. Papoutsoglou P, Pineau R, Leroux R, Louis C, L'Haridon A, Foretek D, Morillon A, Banales JM, Gilot
Category: News
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SULF1 positive fibroblast regulate lizard tail regeneration induced by hedgehog signaling
Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis. Vonk AC, Zhao X, Pan Z, Hudnall ML, Oakes CG, Lopez GA, Hasel-Kolossa
Category: News
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Structure-function of an exostosin heterodimer (EXT1 and EXT2) that extends HSPG polymers
Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Li H, Chapla D, Amos RA, Ramiah A, Moremen KW, Li H. Nat Chem Biol. 2023 May;19(5):565-574. doi: 10.1038/s41589-022-01
Category: News
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EXTL3 selects heparan sulfate synthesis over chondroitin sulfation of glycosaminoglycans
Molecular mechanism of decision-making in glycosaminoglycan biosynthesis. Sammon D, Krueger A, Busse-Wicher M, Morgan RM, Haslam SM, Schumann B, Briggs DC, Hohenester E. Nat Commun. 2023 Oct 13;14(1)
Category: News
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Our paper on SULF2-promoted invasiveness of HNSCC just published
Our paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou, Julius Be
Category: News
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Josh Tu joins the CTGRC for his PhD research rotation
Josh is a first year PhD student of Biochemistry and Molecular & Cellular Biology. He studies inhibition of the heparan 6-O-endosulfatase enzymes by marine fucosylated chondroitins as part of his res
Category: News
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Reem Aljuhani presents her studies of heparan-6-O-endosulfatatses at a BMCB seminar series
Reem presents her discoveries on the “Expression and characterization of extracellular heparan 6-O-endosulfatases Sulf1 and Sulf2” at the Biochemistry and Molecular & Cellular Biology (BMCB) seminar
Category: News
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New details on the function of N-glycans in the FcγRIIIa interaction with IgG
A paper by Van Coillie et al. shows that afucosylated N-glycans of IgG have highest affinity for the oligomannose FcγRIIIa, a glycan structure commonly found on Asn162 on FcγRIIIa expressed by NK cel
Category: News
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Dr. Panigrahi presents a poster on the detection of liver fibrosis at the 2023 SFG meeting in Hawaii
His poster “Serologic LC-MS/MS-PRM of IgG N-glycoform G0FN and sialylated HPX O-glycoforms effectively identifies progressing liver fibrosis” is co-authored byAswini Panigrahi1,2, Lihua Zhang1,2, Jul
Category: News
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Dr. Benicky presents a poster on SULF activity measurements at the 2023 SFG meeting in Hawaii
His poster “A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers” is co-authored by Julius Benicky1, Jian Liu2, Zhangjie Wang3, Vijayakanth Pagadala3, Aswini Panigrahi1, Mi
Category: News