News

June 25th, 2024

6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets. Han M, Zhu H, Chen X, Luo X. Am J Cancer Res. 2024 Feb 25;14(2):897-916. doi:…

June 25th, 2024

Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies. Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z,…

June 25th, 2024

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC,…

June 25th, 2024

A biological guide to glycosaminoglycans: current perspectives and pending questions. Ricard-Blum S, Vivès RR, Schaefer L, Götte M, Merline R, Passi A, Heldin P, Magalhães A, Reis CA, Skandalis…

June 25th, 2024

Aspartate β-Hydroxylase Is Upregulated in Head and Neck Squamous Cell Carcinoma and Regulates Invasiveness in Cancer Cell Models. Mukherjee P, Zhou X, Galli S, Davidson B, Zhang L, Ahn J, Aljuhani…

June 25th, 2024

Congrats to Amy Lum, undergraduate student researcher, on receipt of a Laidlaw scholarship supporting her research at the…

June 25th, 2024

Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Xinheng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang…

June 25th, 2024

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. Mol Cell Proteomics. 2024…

February 18th, 2024

A study of LCM microdissected tumors analyzing proteins in tumor epithelial and stroma fractions associated with node positivity and poor survival of HNSCC patients. DIA-PASEF proteomic analysis of…

February 12th, 2024

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec…

February 12th, 2024

Purification and in vitro Characterization of Human Extracellular Heparan 6-O-Endo-Sulfatases Sulf1 and Sulf2. Aljuhani R, Benicky J, Zhang L, Liu J, Pomin VH, Goldman R. ASBMB San Antonio, March…

February 12th, 2024

A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers. Benicky J, Liu J, Wang Z, Pagadala V, Panigrahi A, Sanda M, Su G, and Goldman R. Society for Glycobiology Annual…

February 12th, 2024

Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts. Mukherjee P, Zhou X, Benicky J, Panigrahi A,…

February 12th, 2024

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R. bioRxiv. 2023 Dec…

February 12th, 2024

TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma. Papoutsoglou P, Pineau R, Leroux R, Louis C, L’Haridon A, Foretek D, Morillon A, Banales JM,…

February 12th, 2024

Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis. Vonk AC, Zhao X, Pan Z, Hudnall ML, Oakes CG, Lopez GA,…

February 12th, 2024

Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Li H, Chapla D, Amos RA, Ramiah A, Moremen KW, Li H. Nat Chem Biol. 2023 May;19(5):565-574. doi:…

February 12th, 2024

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis. Sammon D, Krueger A, Busse-Wicher M, Morgan RM, Haslam SM, Schumann B, Briggs DC, Hohenester E. Nat Commun. 2023 Oct…

October 26th, 2023

Our paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou,…

October 15th, 2023

Josh is a first year PhD student of Biochemistry and Molecular & Cellular Biology. He studies inhibition of the heparan 6-O-endosulfatase enzymes by marine fucosylated chondroitins as part of…

October 15th, 2023

Reem presents her discoveries on the “Expression and characterization of extracellular heparan 6-O-endosulfatases Sulf1 and Sulf2” at the Biochemistry and Molecular & Cellular Biology (BMCB)…

October 15th, 2023

A paper by Van Coillie et al. shows that afucosylated N-glycans of IgG have highest affinity for the oligomannose FcγRIIIa, a glycan structure commonly found on Asn162 on FcγRIIIa expressed by NK…

October 15th, 2023

His poster “Serologic LC-MS/MS-PRM of IgG N-glycoform G0FN and sialylated HPX O-glycoforms effectively identifies progressing liver fibrosis” is co-authored byAswini Panigrahi1,2, Lihua…

October 15th, 2023

His poster “A 6-O-endosulfatase Activity Assay Based on Synthetic Heparan Sulfate Oligomers” is co-authored by Julius Benicky1, Jian Liu2, Zhangjie Wang3, Vijayakanth Pagadala3, Aswini…

October 15th, 2023

A paper by Sorensen et al. identifies two compounds that mediate reversible fragmentation of the Golgi system without affecting secretion; this leads to expression of truncated O-glycans or to the…

October 15th, 2023

A paper by Zaki et al. shows that SULF2 is produced in part by cancer cells but that majority of the SULF2 enzyme is supplied by cancer assicated fibroblasts which correlates with poor prognosis.…

October 15th, 2023

The paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou,…

October 15th, 2023

A paper by Chongsaritsinsuk et al. expose mucin-type O-glycosylation of the T cell immunoglobulin and mucin-domain containing family of proteins (TIMs) and their structure-function models.…

July 13th, 2023

A 6-O-endosulfatase activity assay based on synthetic heparan sulfate oligomers. Benicky J, Sanda M, Panigrahi A, Liu J, Wang Z, Pagadala V, Su G, Goldman R. Glycobiology. 2023 33(5):384-395. doi:…

July 13th, 2023

Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma? Zaki MYW, Alhasan SF, Shukla R, McCain M, Laszczewska M, Geh D, Patman GL, Televantou D,…

July 13th, 2023

Sulfatase 2 Along with Syndecan 1 and Glypican 3 Serum Levels are Associated with a Prognostic Value in Patients with Alcoholic Cirrhosis-Related Advanced Hepatocellular Carcinoma. Mouhoubi N,…

July 13th, 2023

TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. Basu A, Champagne RN, Patel NG, Nicholson ED, Weiss RJ. J Biol Chem. 2023 Jun;299(6):104713. doi:…

July 13th, 2023

HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J,…

February 24th, 2023

LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, Khan K, Kroemer A, Wang LX, Goldman R. J…

February 23rd, 2023

Dr. Goldman presents on the Heparan 6-O-endosulfatases in cancer diseases at the Czech Annual Cancer Research Meeting in Olomouc, December 1 2022:…

February 23rd, 2023

The Development of a Gleason Score-Related Gene Signature for Predicting the Prognosis of Prostate Cancer. Yimamu Y, Yang X, Chen J, Luo C, Xiao W, Guan H, Wang D. J Clin Med. 2022 Dec…

February 23rd, 2023

Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies. Yang Y, Ahn J, Edwards NJ, Benicky J, Rozeboom AM, Davidson B, Karamboulas…

February 23rd, 2023

Noninvasive detection of any-stage cancer using free glycosaminoglycans. Bratulic S, Limeta A, Dabestani S, Birgisson H, Enblad G, Stålberg K, Hesselager G, Häggman M, Höglund M, Simonson OE,…

February 23rd, 2023

A multiplexed microflow LC-MS/MS-PRM assay for serologic quantification of IgG N- and HPX O- glycoforms in liver fibrosis. Panigrahi A, Zhang L, Benicky J, Sanda M, Ahn J, Goldman R. Sci Rep. 2023…

February 23rd, 2023

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC,…

February 23rd, 2023

The glycan structure dictionary-a dictionary describing commonly used glycan structure terms. Vora J, Navelkar R, Vijay-Shanker K, Edwards N, Martinez K, Ding X, Wang T, Su P, Ross K, Lisacek F,…

February 23rd, 2023

HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J,…

February 23rd, 2023

LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, Khan K, Kroemer A, Wang LX, Goldman R. J…

October 19th, 2022

Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts. Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh…

October 19th, 2022

Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors. Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Hung SC. Front Chem. 2022 Jul…

October 19th, 2022

An update on the function of the heparan 6-O-endosulfatases (SULF1 and SULF2) in cancer disease is now under review and deposited on…

October 19th, 2022

Congrats to Reem Aljuhani on a successful Phase 2 exam in her PhD program!! She presented a paper on “Heparan sulfate binding proteins dependent on 6-O-sulfation in Head and neck squamous cells…

October 19th, 2022

The studies target analysis of the structure and function of the heparan 6-O-endosulfatases and are designed to generate inhibitors and antibodies specific to these important…

October 19th, 2022

We will be starting soon a collaborative SBIR research together with Prof. Jian Liu and his colleagues at Glycan Therapeutics. The award examines synthetic probes for the activity of the…

October 19th, 2022

Sincere congrats to Carolyn R. Bertozzi on her Nobel Prize shared with Morten P. Medal and K. Barry Sharpless!! Carolyn walks with grace the boundary of chemistry and biology and she continues to…