Archive: News
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Discovery of global inhibitors of cellular glycosylation
A paper by Sorensen et al. identifies two compounds that mediate reversible fragmentation of the Golgi system without affecting secretion; this leads to expression of truncated O-glycans or to the in
Category: News
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SULF2 derives mainly from cancer associated fibroblasts in hepatocellular cancers
A paper by Zaki et al. shows that SULF2 is produced in part by cancer cells but that majority of the SULF2 enzyme is supplied by cancer assicated fibroblasts which correlates with poor prognosis. doi
Category: News
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Dr. Mukherjee et al. share a preprint on the SULF2-supported invasion of HNSC cells in BioRxiv
The paper “Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts” by Pritha Mukherjee, Xin Zhou, Julius Be
Category: News
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An update on the glycoproteomics of the TIM family of immune checkpoint inhibitors
A paper by Chongsaritsinsuk et al. expose mucin-type O-glycosylation of the T cell immunoglobulin and mucin-domain containing family of proteins (TIMs) and their structure-function models. doi:10.103
Category: News
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Congrats to Dr. Benicky on a paper on the quantification of SULF activity
A 6-O-endosulfatase activity assay based on synthetic heparan sulfate oligomers. Benicky J, Sanda M, Panigrahi A, Liu J, Wang Z, Pagadala V, Su G, Goldman R. Glycobiology. 2023 33(5):384-395. doi: 1
Category: News
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SULF2 is supplied to HCC tissues by cancer associated fibroblasts
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma? Zaki MYW, Alhasan SF, Shukla R, McCain M, Laszczewska M, Geh D, Patman GL, Televantou D, Whitehea
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SULF2, GPC3, and SDC1 in serum predict poor outcomes in HCC
Sulfatase 2 Along with Syndecan 1 and Glypican 3 Serum Levels are Associated with a Prognostic Value in Patients with Alcoholic Cirrhosis-Related Advanced Hepatocellular Carcinoma. Mouhoubi N, Bamba-
Category: News
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Regulation of heparan sulfate assembly by TFCP2
TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. Basu A, Champagne RN, Patel NG, Nicholson ED, Weiss RJ. J Biol Chem. 2023 Jun;299(6):104713. doi: 10.1016/j.
Category: News
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An update on fragmentation of glycopeptides from Dr. Sanda’s group
HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J, Z
Category: News
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Congrats to Drs. Sanda and Panigrahi on significantly improved LC-MS/MS quantification of glycopeptides
LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, Khan K, Kroemer A, Wang LX, Goldman R. J P
Category: News