Archive: News
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A nice study of SARS-CoV-2 binding to heparan sulfate
Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate. Vaibhav Tiwari, Ritesh Tandon, Nehru Viji Sankaranarayanan, Jacob C. Beer, Ellen K. K
Category: News
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Advances in the studies of SARS-CoV-2 O-glycosylation
Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure. Zhijue Xu, Xin Ku, Jiaqi Tian, Han Zhang, Jingli Hou, Can Zhang, Jingjing S
Category: News
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A nice summary of Glycosaminoglycan–Protein Interactions
Glycosaminoglycan-Protein Interactions: The First Draft of the Glycosaminoglycan Interactome. Vallet SD, Clerc O, Ricard-Blum S. J Histochem Cytochem. 2021 Feb;69(2):93-104. doi: 10.1369/002215542094
Category: News
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A nice development in SULF-2 research: it is a proteoglycan
“Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity” Rana El Masri, Amal Seffouh, Caroline Roelants, Ilham Seffouh, Evelyne Gout, Juli
Category: News
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A paper on the glycopeptides of SARS CoV-2 displayed by MHCII to be published soon in Cell Reports
Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells. Parker R, Partridge T, Wormald C, Kawahara R, Stalls V, Aggelakopoulou M, Parker J, Doherty R
Category: News
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Sialic acid on ACE2 and heparan sulfation modify SARS-CoV-2 infectivity
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yua
Category: News
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Dr. Sanda collaborates with SCIEX researchers on CESI TripleTOF LC-MS/MS analysis of Adalimumab glycoforms
The results were published in a Sciex release (https://sciex.com/content/dam/SCIEX/pdf/tech-notes/all/CESI_mAb.pdf) and presented by Mila at the US HUPO 2021 conference, virtual, 03/08/2021: “Site-sp
Category: News
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An elegant method for selective de-glycosylation of O-GlcNAcylated proteins in cells with application to transcriptional regulation of c-Jun and c-Fos
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase. Ge Y, Ramirez DH, Yang B, D'Souza AK, Aonbangkhen C, Wong S, Woo CM. Nat Chem Biol. 2021 Mar 8. doi: 10.1038/s415
Category: News
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CTGRC researchers participate in an inter-laboratory glycoproteomics study in review at Nature Methods
"Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Glycopeptide Data." Rebeca Kawahara, Kathirvel Alagesan, Marshall Bern, Weiqian Cao, Rober
Category: News
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A new report on lysosomal exit of SARS CoV-2 from infected cells
"β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway" Sourish Ghosh, Teegan A Dellibovi-Ragheb, Adeline Kerviel, Eowyn Pak, Qi Qiu, Matthew Fisher, Peter M Takvoria
Category: News